The wreck involves four tractor-trailers and three passenger vehicles. It is blocking all lanes of the roadway.
One of the trucks is on top of one of the passenger vehicles, according to the Georgia Department of Transportation.
GDOT says motorists should completely avoid the Perimeter in DeKalb County near I-20.
Southbound delays appear to be extending back nearly to Memorial Drive. There are also building delays on Interstate 20 in both directions approaching I-285.
There is no estimate as to when traffic will return to normal on that section of roadway.